YGL120C

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Systematic name YGL120C
Gene name PRP43
Aliases JA1
Feature type ORF, Verified
Coordinates Chr VII:283937..281634
Primary SGDID S000003088


Description of YGL120C: RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome[1][2][3][4]




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References

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  1. Arenas JE and Abelson JN (1997) Prp43: An RNA helicase-like factor involved in spliceosome disassembly. Proc Natl Acad Sci U S A 94(22):11798-802 SGD PMID 9342317
  2. Combs DJ, et al. (2006) Prp43p is a DEAH-box spliceosome disassembly factor essential for ribosome biogenesis. Mol Cell Biol 26(2):523-34 SGD PMID 16382144
  3. Martin A, et al. (2002) Prp43 is an essential RNA-dependent ATPase required for release of lariat-intron from the spliceosome. J Biol Chem 277(20):17743-50 SGD PMID 11886864
  4. de la Cruz J, et al. (1999) Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families. Trends Biochem Sci 24(5):192-8 SGD PMID 10322435

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