YGL092W
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| Systematic name | YGL092W |
| Gene name | NUP145 |
| Aliases | RAT10 |
| Feature type | ORF, Verified |
| Coordinates | Chr VII:337906..341859 |
| Primary SGDID | S000003060 |
Description of YGL092W: Essential protein with distinct roles in two nuclear pore subcomplexes; catalyzes its own proteolytic cleavage in vivo to generate a C-terminal fragment that is a structural component of the Nup84p subcomplex (with roles in NPC biogenesis and localization of genes to the nuclear periphery), and an N-terminal fragment that is one of several FG-nucleoporins within the NPC central core directly responsible for nucleocytoplasmic transport; homologous to human NUP98[1][2][3][4][5][6][7][8]
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References
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- ↑ Fernandez-Martinez J and Rout MP (2009) Nuclear pore complex biogenesis. Curr Opin Cell Biol 21(4):603-12 SGD PMID 19524430
- ↑ Fernandez-Martinez J, et al. (2012) Structure-function mapping of a heptameric module in the nuclear pore complex. J Cell Biol () SGD PMID 22331846
- ↑ Fiserova J, et al. (2010) Facilitated transport and diffusion take distinct spatial routes through the nuclear pore complex. J Cell Sci 123(Pt 16):2773-80 SGD PMID 20647373
- ↑ Menon BB, et al. (2005) Reverse recruitment: the Nup84 nuclear pore subcomplex mediates Rap1/Gcr1/Gcr2 transcriptional activation. Proc Natl Acad Sci U S A 102(16):5749-54 SGD PMID 15817685
- ↑ Teixeira MT, et al. (1997) Two functionally distinct domains generated by in vivo cleavage of Nup145p: a novel biogenesis pathway for nucleoporins. EMBO J 16(16):5086-97 SGD PMID 9305650
- ↑ Teixeira MT, et al. (1999) Self-catalyzed cleavage of the yeast nucleoporin Nup145p precursor. J Biol Chem 274(45):32439-44 SGD PMID 10542288
- ↑ Therizols P, et al. (2006) Telomere tethering at the nuclear periphery is essential for efficient DNA double strand break repair in subtelomeric region. J Cell Biol 172(2):189-99 SGD PMID 16418532
- ↑ Tous C, et al. (2011) A novel assay identifies transcript elongation roles for the Nup84 complex and RNA processing factors. EMBO J 30(10):1953-64 SGD PMID 21478823
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