YGL025C
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| Systematic name | YGL025C |
| Gene name | PGD1 |
| Aliases | HRS1, MED3 |
| Feature type | ORF, Verified |
| Coordinates | Chr VII:449957..448764 |
| Primary SGDID | S000002993 |
Description of YGL025C: Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor[1][2][3][4][5]
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References
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- ↑ Guglielmi B, et al. (2004) A high resolution protein interaction map of the yeast Mediator complex. Nucleic Acids Res 32(18):5379-91 SGD PMID 15477388
- ↑ Lee M, et al. (2000) Genetic analysis of the role of Pol II holoenzyme components in repression by the Cyc8-Tup1 corepressor in yeast. Genetics 155(4):1535-42 SGD PMID 10924455
- ↑ Myers LC, et al. (1999) Mediator protein mutations that selectively abolish activated transcription. Proc Natl Acad Sci U S A 96(1):67-72 SGD PMID 9874773
- ↑ Papamichos-Chronakis M, et al. (2000) Hrs1/Med3 is a Cyc8-Tup1 corepressor target in the RNA polymerase II holoenzyme. J Biol Chem 275(12):8397-403 SGD PMID 10722672
- ↑ Reeves WM and Hahn S (2003) Activator-independent functions of the yeast mediator sin4 complex in preinitiation complex formation and transcription reinitiation. Mol Cell Biol 23(1):349-58 SGD PMID 12482986
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