YER173W

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Systematic name YER173W
Gene name RAD24
Aliases RS1
Feature type ORF, Verified
Coordinates Chr V:536300..538279
Primary SGDID S000000975


Description of YER173W: Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein[1][2][3]




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References

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  1. Lydall D, et al. (1996) A meiotic recombination checkpoint controlled by mitotic checkpoint genes. Nature 383(6603):840-3 SGD PMID 8893012
  2. Majka J and Burgers PM (2003) Yeast Rad17/Mec3/Ddc1: a sliding clamp for the DNA damage checkpoint. Proc Natl Acad Sci U S A 100(5):2249-54 SGD PMID 12604797
  3. Shinohara M, et al. (2003) The mitotic DNA damage checkpoint proteins Rad17 and Rad24 are required for repair of double-strand breaks during meiosis in yeast. Genetics 164(3):855-65 SGD PMID 12871899

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