YER123W

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Systematic name YER123W
Gene name YCK3
Aliases CKI3
Feature type ORF, Verified
Coordinates Chr V:404813..406387
Primary SGDID S000000925


Description of YER123W: Palmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares essential functions with Hrr25p; regulates vesicle fusion in AP-3 pathway[1][2][3][4]




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References

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  1. Anand VC, et al. (2009) Genome-wide analysis of AP-3-dependent protein transport in yeast. Mol Biol Cell 20(5):1592-604 SGD PMID 19116312
  2. Lagrassa TJ and Ungermann C (2005) The vacuolar kinase Yck3 maintains organelle fragmentation by regulating the HOPS tethering complex. J Cell Biol 168(3):401-14 SGD PMID 15684030
  3. Sun B, et al. (2004) The yeast casein kinase Yck3p is palmitoylated, then sorted to the vacuolar membrane with AP-3-dependent recognition of a YXXPhi adaptin sorting signal. Mol Biol Cell 15(3):1397-406 SGD PMID 14668479
  4. Wang X, et al. (1996) Prenylated isoforms of yeast casein kinase I, including the novel Yck3p, suppress the gcs1 blockage of cell proliferation from stationary phase. Mol Cell Biol 16(10):5375-85 SGD PMID 8816449

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