YER100W
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| Systematic name | YER100W |
| Gene name | UBC6 |
| Aliases | DOA2 |
| Feature type | ORF, Verified |
| Coordinates | Chr V:359562..360314 |
| Primary SGDID | S000000902 |
Description of YER100W: Ubiquitin-conjugating enzyme involved in ER-associated protein degradation; located at the cytosolic side of the ER membrane; tail region contains a transmembrane segment at the C-terminus; substrate of the ubiquitin-proteasome pathway[1][2][3][4]
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References
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- ↑ Biederer T, et al. (1996) Degradation of subunits of the Sec61p complex, an integral component of the ER membrane, by the ubiquitin-proteasome pathway. EMBO J 15(9):2069-76 SGD PMID 8641272
- ↑ Gilon T, et al. (2000) Degradation signals recognized by the Ubc6p-Ubc7p ubiquitin-conjugating enzyme pair. Mol Cell Biol 20(19):7214-9 SGD PMID 10982838
- ↑ Sommer T and Jentsch S (1993) A protein translocation defect linked to ubiquitin conjugation at the endoplasmic reticulum. Nature 365(6442):176-9 SGD PMID 8396728
- ↑ Walter J, et al. (2001) Sec61p-independent degradation of the tail-anchored ER membrane protein Ubc6p. EMBO J 20(12):3124-31 SGD PMID 11406589
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