YER093C
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| Systematic name | YER093C |
| Gene name | TSC11 |
| Aliases | AVO3 |
| Feature type | ORF, Verified |
| Coordinates | Chr V:347612..343320 |
| Primary SGDID | S000000895 |
Description of YER093C: Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domain[1][2][3][4][5]
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References
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- ↑ Beeler T, et al. (1998) The Saccharomyces cerevisiae TSC10/YBR265w gene encoding 3-ketosphinganine reductase is identified in a screen for temperature-sensitive suppressors of the Ca2+-sensitive csg2Delta mutant. J Biol Chem 273(46):30688-94 SGD PMID 9804843
- ↑ Ho HL, et al. (2005) Saccharomyces cerevisiaeTSC11/AVO3 participates in regulating cell integrity and functionally interacts with components of the Tor2 complex. Curr Genet 47(5):273-88 SGD PMID 15809876
- ↑ Jacinto E and Hall MN (2003) Tor signalling in bugs, brain and brawn. Nat Rev Mol Cell Biol 4(2):117-26 SGD PMID 12563289
- ↑ Loewith R, et al. (2002) Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell 10(3):457-68 SGD PMID 12408816
- ↑ Wedaman KP, et al. (2003) Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae. Mol Biol Cell 14(3):1204-20 SGD PMID 12631735
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