YEL013W

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Systematic name YEL013W
Gene name VAC8
Aliases YEB3
Feature type ORF, Verified
Coordinates Chr V:128825..130561
Primary SGDID S000000739


Description of YEL013W: Phosphorylated and palmitoylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions[1][2][3][4]




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Interactions

Physical

Physical interaction with VAC17
Immunoprecipitating Vac17p with sheep anti-Vac17p antibody coprecipitates Vac8p. [5] [6]


Two Hybrid

Two Hybrid interaction with VAC17
Residues 290-380 of Vac17p interact with Vac8p in a yeast two-hybrid analysis. [5] [6]





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References

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  1. Pan X, et al. (2000) Nucleus-vacuole junctions in Saccharomyces cerevisiae are formed through the direct interaction of Vac8p with Nvj1p. Mol Biol Cell 11(7):2445-57 SGD PMID 10888680
  2. Scott SV, et al. (2000) Apg13p and Vac8p are part of a complex of phosphoproteins that are required for cytoplasm to vacuole targeting. J Biol Chem 275(33):25840-9 SGD PMID 10837477
  3. Subramanian K, et al. (2006) Palmitoylation determines the function of Vac8 at the yeast vacuole. J Cell Sci 119(Pt 12):2477-85 SGD PMID 16720644
  4. Wang YX, et al. (1998) Vac8p, a vacuolar protein with armadillo repeats, functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole. J Cell Biol 140(5):1063-74 SGD PMID 9490720
  5. 5.0 5.1 Tang F, et al. (2003) Regulated degradation of a class V myosin receptor directs movement of the yeast vacuole. Nature 422(6927):87-92 SGD PMID 12594460
  6. 6.0 6.1 submitted by Fusheng Tang on 2003-03-17

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