YDR496C

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Systematic name YDR496C
Gene name PUF6
Aliases
Feature type ORF, Verified
Coordinates Chr IV:1443403..1441433
Primary SGDID S000002904


Description of YDR496C: Pumilio-homology domain protein that binds the 3' UTR of ASH1 mRNA and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA; also co-sediments with the 60S ribosomal subunit and is required for its biogenesis[1][2]




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References

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  1. Gu W, et al. (2004) A new yeast PUF family protein, Puf6p, represses ASH1 mRNA translation and is required for its localization. Genes Dev 18(12):1452-65 SGD PMID 15198983
  2. Li Z, et al. (2009) Rational extension of the ribosome biogenesis pathway using network-guided genetics. PLoS Biol 7(10):e1000213 SGD PMID 19806183

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