YDR363W

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Systematic name YDR363W
Gene name ESC2
Aliases
Feature type ORF, Verified
Coordinates Chr IV:1199183..1200553
Primary SGDID S000002771


Description of YDR363W: Sumo-like domain protein; prevents accumulation of toxic intermediates during replication-associated recombinational repair; roles in silencing, lifespan, chromatid cohesion and the intra-S-phase DNA damage checkpoint; RENi family member[1][2][3][4][5]




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References

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  1. Choi K, et al. (2010) The Smc5/6 complex and Esc2 influence multiple replication-associated recombination processes in Saccharomyces cerevisiae. Mol Biol Cell 21(13):2306-14 SGD PMID 20444977
  2. Dhillon N and Kamakaka RT (2000) A histone variant, Htz1p, and a Sir1p-like protein, Esc2p, mediate silencing at HMR. Mol Cell 6(4):769-80 SGD PMID 11090616
  3. Mankouri HW, et al. (2009) Esc2 and Sgs1 act in functionally distinct branches of the homologous recombination repair pathway in Saccharomyces cerevisiae. Mol Biol Cell 20(6):1683-94 SGD PMID 19158388
  4. Novatchkova M, et al. (2005) Proteins with two SUMO-like domains in chromatin-associated complexes: the RENi (Rad60-Esc2-NIP45) family. BMC Bioinformatics 6():22 SGD PMID 15698469
  5. Ohya T, et al. (2008) A SUMO-Like Domain Protein, Esc2, Is Required for Genome Integrity and Sister Chromatid Cohesion in Saccharomyces cerevisiae. Genetics 180(1):41-50 SGD PMID 18757937

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