YDR335W

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Systematic name YDR335W
Gene name MSN5
Aliases KAP142, STE21
Feature type ORF, Verified
Coordinates Chr IV:1141168..1144842
Primary SGDID S000002743


Description of YDR335W: Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm[1][2][3][4][5][6]




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References

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  1. Alepuz PM, et al. (1999) The Saccharomyces cerevisiae RanGTP-binding protein msn5p is involved in different signal transduction pathways. Genetics 153(3):1219-31 SGD PMID 10545454
  2. Blondel M, et al. (1999) Nuclear export of Far1p in response to pheromones requires the export receptor Msn5p/Ste21p. Genes Dev 13(17):2284-300 SGD PMID 10485850
  3. Kaffman A, et al. (1998) The receptor Msn5 exports the phosphorylated transcription factor Pho4 out of the nucleus. Nature 396(6710):482-6 SGD PMID 9853758
  4. Murthi A, et al. (2010) Regulation of tRNA Bidirectional Nuclear-Cytoplasmic Trafficking in Saccharomyces cerevisiae. Mol Biol Cell 21(4):639-49 SGD PMID 20032305
  5. Queralt E and Igual JC (2003) Cell cycle activation of the Swi6p transcription factor is linked to nucleocytoplasmic shuttling. Mol Cell Biol 23(9):3126-40 SGD PMID 12697814
  6. Yoshida K and Blobel G (2001) The karyopherin Kap142p/Msn5p mediates nuclear import and nuclear export of different cargo proteins. J Cell Biol 152(4):729-40 SGD PMID 11266464

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