YDR139C
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| Systematic name | YDR139C |
| Gene name | RUB1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:733924..733618 |
| Primary SGDID | S000002546 |
Description of YDR139C: Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme)[1][2][3][4]
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References
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- ↑ Hochstrasser M (2000) Biochemistry. All in the ubiquitin family. Science 289(5479):563-4 SGD PMID 10939967
- ↑ Lammer D, et al. (1998) Modification of yeast Cdc53p by the ubiquitin-related protein rub1p affects function of the SCFCdc4 complex. Genes Dev 12(7):914-26 SGD PMID 9531531
- ↑ Laplaza JM, et al. (2004) Saccharomyces cerevisiae ubiquitin-like protein Rub1 conjugates to cullin proteins Rtt101 and Cul3 in vivo. Biochem J 377(Pt 2):459-67 SGD PMID 14519104
- ↑ Liakopoulos D, et al. (1998) A novel protein modification pathway related to the ubiquitin system. EMBO J 17(8):2208-14 SGD PMID 9545234
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