YDR069C

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Systematic name YDR069C
Gene name DOA4
Aliases DOS1, MUT4, NPI2, SSV7, UBP4
Feature type ORF, Verified
Coordinates Chr IV:587719..584939
Primary SGDID S000002476


Description of YDR069C: Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole[1][2][3]




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References

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  1. Jump up Amerik AY, et al. (2000) The Doa4 deubiquitinating enzyme is functionally linked to the vacuolar protein-sorting and endocytic pathways. Mol Biol Cell 11(10):3365-80 SGD PMID 11029042
  2. Jump up Singer JD, et al. (1996) Coordinating DNA replication to produce one copy of the genome requires genes that act in ubiquitin metabolism. Mol Cell Biol 16(4):1356-66 SGD PMID 8657109
  3. Jump up Swaminathan S, et al. (1999) The Doa4 deubiquitinating enzyme is required for ubiquitin homeostasis in yeast. Mol Biol Cell 10(8):2583-94 SGD PMID 10436014

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