YDL217C

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Systematic name YDL217C
Gene name TIM22
Aliases
Feature type ORF, Verified
Coordinates Chr IV:68606..67983
Primary SGDID S000002376


Description of YDL217C: Essential core component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported[1][2][3][4][5][6]




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References

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  1. Jensen RE and Dunn CD (2002) Protein import into and across the mitochondrial inner membrane: role of the TIM23 and TIM22 translocons. Biochim Biophys Acta 1592(1):25-34 SGD PMID 12191765
  2. Kerscher O, et al. (2000) Tim18p is a new component of the Tim54p-Tim22p translocon in the mitochondrial inner membrane. Mol Biol Cell 11(1):103-16 SGD PMID 10637294
  3. Koehler CM, et al. (2000) Tim18p, a new subunit of the TIM22 complex that mediates insertion of imported proteins into the yeast mitochondrial inner membrane. Mol Cell Biol 20(4):1187-93 SGD PMID 10648604
  4. Rehling P, et al. (2003) Insertion of hydrophobic membrane proteins into the inner mitochondrial membrane--a guided tour. J Mol Biol 326(3):639-57 SGD PMID 12581629
  5. Rehling P, et al. (2003) Protein insertion into the mitochondrial inner membrane by a twin-pore translocase. Science 299(5613):1747-51 SGD PMID 12637749
  6. Sirrenberg C, et al. (1996) Import of carrier proteins into the mitochondrial inner membrane mediated by Tim22. Nature 384(6609):582-5 SGD PMID 8955274

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