YDL205C
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| Systematic name | YDL205C |
| Gene name | HEM3 |
| Aliases | OLE2 |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:93745..92762 |
| Primary SGDID | S000002364 |
Description of YDL205C: Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme[1][2]
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References
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- Jump up ↑ Gollub EG, et al. (1977) Yeast mutants deficient in heme biosynthesis and a heme mutant additionally blocked in cyclization of 2,3-oxidosqualene. J Biol Chem 252(9):2846-54 SGD PMID 323256
- Jump up ↑ Keng T, et al. (1992) Structure and regulation of yeast HEM3, the gene for porphobilinogen deaminase. Mol Gen Genet 234(2):233-43 SGD PMID 1508149
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