YDL154W

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Systematic name YDL154W
Gene name MSH5
Aliases
Feature type ORF, Verified
Coordinates Chr IV:178334..181039
Primary SGDID S000002313


Description of YDL154W: Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans[1][2][3]




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References

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  1. Bawa S and Xiao W (2003) A single amino acid substitution in MSH5 results in DNA alkylation tolerance. Gene 315:177-82 SGD PMID 14557077
  2. Pochart P, et al. (1997) Conserved properties between functionally distinct MutS homologs in yeast. J Biol Chem 272(48):30345-9 SGD PMID 9374523
  3. Winand NJ, et al. (1998) Cloning and characterization of the human and Caenorhabditis elegans homologs of the Saccharomyces cerevisiae MSH5 gene. Genomics 53(1):69-80 SGD PMID 9787078

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