YDL115C
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| Systematic name | YDL115C |
| Gene name | IWR1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:255126..253995 |
| Primary SGDID | S000002273 |
Description of YDL115C: RNA polymerase II transport factor, conserved from yeast to humans; involved in both basal and regulated transcription from RNA polymerase II (RNAP II) promoters, but not itself a transcription factor; interacts with most of the RNAP II subunits; nucleo-cytoplasmic shuttling protein; deletion causes hypersensitivity to K1 killer toxin[1][2][3][4]
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References
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- ↑ Czeko E, et al. (2011) Iwr1 Directs RNA Polymerase II Nuclear Import. Mol Cell 42(2):261-6 SGD PMID 21504834
- ↑ Krogan NJ, et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature 440(7084):637-43 SGD PMID 16554755
- ↑ Page N, et al. (2003) A Saccharomyces cerevisiae genome-wide mutant screen for altered sensitivity to K1 killer toxin. Genetics 163(3):875-94 SGD PMID 12663529
- ↑ Peiro-Chova L and Estruch F (2009) The yeast RNA polymerase II-associated factor Iwr1p is involved in the basal and regulated transcription of specific genes. J Biol Chem 284(42):28958-67 SGD PMID 19679657
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