YCL026C-A
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| Systematic name | YCL026C-A |
| Gene name | FRM2 |
| Aliases | YCLX08C |
| Feature type | ORF, Verified |
| Coordinates | Chr III:75285..74704 |
| Primary SGDID | S000000589 |
Description of YCL026C-A: Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin[1][2][3][4][5][6][7]
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References
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- Jump up ↑ Azevedo D, et al. (2007) The S. cerevisiae Yap1 and Yap2 transcription factors share a common cadmium-sensing domain. FEBS Lett 581(2):187-195 SGD PMID 17187783
- Jump up ↑ Bang SY, et al. (2012) Confirmation of Frm2 as a novel nitroreductase in Saccharomyces cerevisiae. Biochem Biophys Res Commun () SGD PMID 22687599
- Jump up ↑ Iwahashi Y, et al. (2006) Mechanisms of patulin toxicity under conditions that inhibit yeast growth. J Agric Food Chem 54(5):1936-42 SGD PMID 16506856
- Jump up ↑ McHale MW, et al. (1996) Identification of a class of Saccharomyces cerevisiae mutants defective in fatty acid repression of gene transcription and analysis of the frm2 gene. Yeast 12(4):319-31 SGD PMID 8701605
- Jump up ↑ Salin H, et al. (2008) Structure and properties of transcriptional networks driving selenite stress response in yeasts. BMC Genomics 9:333 SGD PMID 18627600
- Jump up ↑ de Oliveira IM, et al. (2007) In silico identification of a new group of specific bacterial and fungal nitroreductases-like proteins. Biochem Biophys Res Commun 355(4):919-25 SGD PMID 17331467
- Jump up ↑ de Oliveira IM, et al. (2010) The role of two putative nitroreductases, Frm2p and Hbn1p, in the oxidative stress response in Saccharomyces cerevisiae. Yeast 27(2):89-102 SGD PMID 19904831
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