YBR252W
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| Systematic name | YBR252W |
| Gene name | DUT1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr II:722611..723054 |
| Primary SGDID | S000000456 |
Description of YBR252W: deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate[1][2][3]
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References
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- Jump up ↑ Gadsden MH, et al. (1993) dUTP pyrophosphatase is an essential enzyme in Saccharomyces cerevisiae. EMBO J 12(11):4425-31 SGD PMID 8223452
- Jump up ↑ Guillet M, et al. (2006) dUTPase activity is critical to maintain genetic stability in Saccharomyces cerevisiae. Nucleic Acids Res 34(7):2056-66 SGD PMID 16617146
- Jump up ↑ Tchigvintsev A, et al. (2011) Structure and activity of the Saccharomyces cerevisiae deoxyuridine triphosphate pyrophosphatase DUT1, an essential housekeeping enzyme. Biochem J () SGD PMID 21548881
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