YBR179C
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| Systematic name | YBR179C |
| Gene name | FZO1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr II:589114..586547 |
| Primary SGDID | S000000383 |
Description of YBR179C: Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system[1][2][3][4][5][6]
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References
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- ↑ Anton F, et al. (2011) Ugo1 and Mdm30 act sequentially during Fzo1-mediated mitochondrial outer membrane fusion. J Cell Sci 124(Pt 7):1126-35 SGD PMID 21385840
- ↑ Cohen MM, et al. (2008) Ubiquitin-Proteasome-dependent Degradation of a Mitofusin, a Critical Regulator of Mitochondrial Fusion. Mol Biol Cell 19(6):2457-64 SGD PMID 18353967
- ↑ Cohen MM, et al. (2011) Sequential requirements for the GTPase domain of the mitofusin Fzo1 and the ubiquitin ligase SCFMdm30 in mitochondrial outer membrane fusion. J Cell Sci 124(Pt 9):1403-10 SGD PMID 21502136
- ↑ Escobar-Henriques M, et al. (2006) Regulation of mitochondrial fusion by the F-box protein Mdm30 involves proteasome-independent turnover of Fzo1. J Cell Biol 173(5):645-50 SGD PMID 16735578
- ↑ Hermann GJ, et al. (1998) Mitochondrial fusion in yeast requires the transmembrane GTPase Fzo1p. J Cell Biol 143(2):359-73 SGD PMID 9786948
- ↑ Rapaport D, et al. (1998) Fzo1p is a mitochondrial outer membrane protein essential for the biogenesis of functional mitochondria in Saccharomyces cerevisiae. J Biol Chem 273(32):20150-5 SGD PMID 9685359
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