YBR140C
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| Systematic name | YBR140C |
| Gene name | IRA1 |
| Aliases | GLC1, PPD1 |
| Feature type | ORF, Verified |
| Coordinates | Chr II:526628..517350 |
| Primary SGDID | S000000344 |
Description of YBR140C: GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase[1][2]
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References
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- ↑ Mitts MR, et al. (1991) Interactions between adenylate cyclase and the yeast GTPase-activating protein IRA1. Mol Cell Biol 11(9):4591-8 SGD PMID 1875942
- ↑ Tanaka K, et al. (1989) IRA1, an inhibitory regulator of the RAS-cyclic AMP pathway in Saccharomyces cerevisiae. Mol Cell Biol 9(2):757-68 SGD PMID 2540426
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