YBR060C

From SGD-Wiki
Jump to: navigation, search

Share your knowledge...Edit this entry! <protect>

Systematic name YBR060C
Gene name ORC2
Aliases RRR1, SIR5
Feature type ORF, Verified
Coordinates Chr II:362514..360652
Primary SGDID S000000264


Description of YBR060C: Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; interacts with Spp1p and with trimethylated histone H3; phosphorylated by Cdc28p[1][2][3]




</protect>

Community Commentary

About Community Commentary. Please share your knowledge!

Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [3] [4]





<protect>

References

See Help:References on how to add references

  1. Bell SP (2002) The origin recognition complex: from simple origins to complex functions. Genes Dev 16(6):659-72 SGD PMID 11914271
  2. Kan J, et al. (2008) Origin Recognition Complex (ORC) Mediates Histone 3 Lysine 4 Methylation through Cooperation with Spp1 in Saccharomyces cerevisiae. J Biol Chem 283(49):33803-7 SGD PMID 18845545
  3. 3.0 3.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415 Cite error: Invalid <ref> tag; name "S000074306" defined multiple times with different content
  4. submitted by Jeff Ubersax on 2004-01-21

See Help:Categories on how to add the wiki page for this gene to a Category </protect>