YAL061W
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Caffeine and Yeast Cells
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| Systematic name | YAL061W |
| Gene name | BDH2 |
| Aliases | |
| Feature type | ORF, Uncharacterized |
| Coordinates | Chr I:33448..34701 |
| Primary SGDID | S000000057 |
Description of YAL061W: Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3[1][2][3][4]
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Community Commentary
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This gene is part of the UW-Stout Orphan Gene Project. Learn more here.
Growth Curve
In a BY4735 background, knocking out YAL061W seems to have a moderate effect on growth rate in log-phase. In this assay, the BY4735 strain's doubling time was 361 minutes, while the YAL061 knock-out strain's doubling time was 469 minutes. (These doubling times are the means of three experiments.)
These two graphs show the growth curve with caffeine. The first graph is the knockout strain and it only had positive effects on the cells. The average doubling time between the three experiments were 777.27 minutes. The second graph showed that caffeine also had a positive effect on the growth curve with the average doubling time for the six different tests being 1245.02 minutes. The results were concluded from the wild type and knockout strand.
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References
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- ↑ Devaux F, et al. (2002) Genome-wide studies on the nuclear PDR3-controlled response to mitochondrial dysfunction in yeast. FEBS Lett 515(1-3):25-8 SGD PMID 11943188
- ↑ Dickinson JR, et al. (2003) The catabolism of amino acids to long chain and complex alcohols in Saccharomyces cerevisiae. J Biol Chem 278(10):8028-34 SGD PMID 12499363
- ↑ Gonzalez E, et al. (2000) Characterization of a (2R,3R)-2,3-butanediol dehydrogenase as the Saccharomyces cerevisiae YAL060W gene product. Disruption and induction of the gene. J Biol Chem 275(46):35876-85 SGD PMID 10938079
- ↑ do Valle Matta MA, et al. (2001) Novel target genes of the yeast regulator Pdr1p: a contribution of the TPO1 gene in resistance to quinidine and other drugs. Gene 272(1-2):111-9 SGD PMID 11470516
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