YPL262W

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Systematic name YPL262W
Gene name FUM1
Aliases
Feature type ORF, Verified
Coordinates Chr XVI:47336..48802
Primary SGDID S000006183


Description of YPL262W: Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria[1][2][3][4]




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References

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  1. Przybyla-Zawislak B, et al. (1999) Genetic and biochemical interactions involving tricarboxylic acid cycle (TCA) function using a collection of mutants defective in all TCA cycle genes. Genetics 152(1):153-66 SGD PMID 10224250
  2. Regev-Rudzki N, et al. (2009) Dual localization of fumarase is dependent on the integrity of the glyoxylate shunt. Mol Microbiol 72(2):297-306 SGD PMID 19415796
  3. Reinders J, et al. (2007) Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase. Mol Cell Proteomics 6(11):1896-906 SGD PMID 17761666
  4. Sass E, et al. (2003) Folding of fumarase during mitochondrial import determines its dual targeting in yeast. J Biol Chem 278(46):45109-16 SGD PMID 12960177

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