YNL299W

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Systematic name YNL299W
Gene name TRF5
Aliases
Feature type ORF, Verified
Coordinates Chr XIV:66517..68445


Description of YNL299W: Poly (A) polymerase involved in nuclear RNA quality control based on: homology with Trf4p, genetic interactions with TRF4 mutants, physical interaction with Mtr4p (TRAMP subunit), and by direct assay; disputed role as a sigma DNA polymerase[1][2][3][4][5]




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References

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  1. Haracska L, et al. (2005) Trf4 and Trf5 proteins of Saccharomyces cerevisiae exhibit poly(A) RNA polymerase activity but no DNA polymerase activity. Mol Cell Biol 25(22):10183-9 SGD PMID 16260630
  2. LaCava J, et al. (2005) RNA degradation by the exosome is promoted by a nuclear polyadenylation complex. Cell 121(5):713-24 SGD PMID 15935758
  3. Vanacova S, et al. (2005) A new yeast poly(A) polymerase complex involved in RNA quality control. PLoS Biol 3(6):e189 SGD PMID 15828860
  4. Wang Z, et al. (2002) Structure/function analysis of the Saccharomyces cerevisiae Trf4/Pol sigma DNA polymerase. Genetics 160(2):381-91 SGD PMID 11861546
  5. Wang Z, et al. (2000) Pol kappa: A DNA polymerase required for sister chromatid cohesion. Science 289(5480):774-9 SGD PMID 10926539

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