Difference between revisions of "YNL255C"

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'''Description of YNL255C:''' RNA binding protein that binds to mRNAs coding for RNA processing factors, chromatin modifiers and GTPases; has sequence and functional similarity to CNBP, a gene involved in myotonic dystrophy type 2; contains seven CCHC zinc-finger motifs<ref name='S000061788'>Brown MP, et al. (2000) Knowledge-based analysis of microarray gene expression data by using support vector machines. Proc Natl Acad Sci U S A 97(1):262-7 {{SGDpaper|S000061788}} PMID 10618406</ref><ref name='S000143268'>Scherrer T, et al. (2011) Defining potentially conserved RNA regulons of homologous zinc-finger RNA-binding proteins. Genome Biol 12(1):R3 {{SGDpaper|S000143268}} PMID 21232131</ref><ref name='S000048854'>Sen-Gupta M, et al. (1997) Sequence analysis of the 33 kb long region between ORC5 and SUI1 from the left arm of chromosome XIV from Saccharomyces cerevisiae. Yeast 13(9):849-60 {{SGDpaper|S000048854}} PMID 9234673</ref><ref name='S000136456'>Tsvetanova NG, et al. (2010) Proteome-Wide Search Reveals Unexpected RNA-Binding Proteins in Saccharomyces cerevisiae.LID - e12671 [pii] PLoS One 5(9)
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'''Description of YNL255C:''' Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2<ref name='S000143933'>Sammons MA, et al. (2011) S. cerevisiae Gis2 interacts with the translation machinery and is orthogonal to myotonic dystrophy type 2 protein ZNF9. Biochem Biophys Res Commun () {{SGDpaper|S000143933}} PMID 21277287</ref><ref name='S000143268'>Scherrer T, et al. (2011) Defining potentially conserved RNA regulons of homologous zinc-finger RNA-binding proteins. Genome Biol 12(1):R3 {{SGDpaper|S000143268}} PMID 21232131</ref><ref name='S000136456'>Tsvetanova NG, et al. (2010) Proteome-Wide Search Reveals Unexpected RNA-Binding Proteins in Saccharomyces cerevisiae.LID - e12671 [pii] PLoS One 5(9)
 
  {{SGDpaper|S000136456}} PMID 20844764</ref>
 
  {{SGDpaper|S000136456}} PMID 20844764</ref>
 
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Revision as of 14:05, 9 February 2011

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Systematic name YNL255C
Gene name GIS2
Aliases
Feature type ORF, Verified
Coordinates Chr XIV:167790..167329
Primary SGDID S000005199


Description of YNL255C: Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2[1][2][3]




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References

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  1. Sammons MA, et al. (2011) S. cerevisiae Gis2 interacts with the translation machinery and is orthogonal to myotonic dystrophy type 2 protein ZNF9. Biochem Biophys Res Commun () SGD PMID 21277287
  2. Scherrer T, et al. (2011) Defining potentially conserved RNA regulons of homologous zinc-finger RNA-binding proteins. Genome Biol 12(1):R3 SGD PMID 21232131
  3. Tsvetanova NG, et al. (2010) Proteome-Wide Search Reveals Unexpected RNA-Binding Proteins in Saccharomyces cerevisiae.LID - e12671 [pii] PLoS One 5(9) SGD PMID 20844764

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