Difference between revisions of "YNL111C"

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'''Description of YNL111C:''' Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; required for sterol C5-6 and fatty acid desaturation<ref name='S000077204'>Rogers KM, et al. (2004) Disruption of the Candida albicans CYB5 gene results in increased azole sensitivity. Antimicrob Agents Chemother 48(9):3425-35 {{SGDpaper|S000077204}} PMID 15328107</ref><ref name='S000062515'>Ohba M, et al. (1979) Mutant and immunochemical studies on the involvement of cytochrome b5 in fatty acid desaturation by yeast microsomes. Biochim Biophys Acta 572(2):352-62 {{SGDpaper|S000062515}} PMID 106893</ref><ref name='S000047307'>Truan G, et al. (1994) Cloning and characterization of a yeast cytochrome b5-encoding gene which suppresses ketoconazole hypersensitivity in a NADPH-P-450 reductase-deficient strain. Gene 142(1):123-7
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'''Description of YNL111C:''' Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation<ref name='S000062024'>Lamb DC, et al. (1999) Biodiversity of the P450 catalytic cycle: yeast cytochrome b5/NADH cytochrome b5 reductase complex efficiently drives the entire sterol 14-demethylation (CYP51) reaction. FEBS Lett 462(3):283-8 {{SGDpaper|S000062024}} PMID 10622712</ref><ref name='S000047307'>Truan G, et al. (1994) Cloning and characterization of a yeast cytochrome b5-encoding gene which suppresses ketoconazole hypersensitivity in a NADPH-P-450 reductase-deficient strain. Gene 142(1):123-7
 
  {{SGDpaper|S000047307}} PMID 8181746</ref>
 
  {{SGDpaper|S000047307}} PMID 8181746</ref>
 
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Revision as of 07:21, 26 February 2009

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Systematic name YNL111C
Gene name CYB5
Aliases
Feature type ORF, Verified
Coordinates Chr XIV:417304..416942
Primary SGDID S000005055


Description of YNL111C: Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation[1][2]




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References

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  1. Lamb DC, et al. (1999) Biodiversity of the P450 catalytic cycle: yeast cytochrome b5/NADH cytochrome b5 reductase complex efficiently drives the entire sterol 14-demethylation (CYP51) reaction. FEBS Lett 462(3):283-8 SGD PMID 10622712
  2. Truan G, et al. (1994) Cloning and characterization of a yeast cytochrome b5-encoding gene which suppresses ketoconazole hypersensitivity in a NADPH-P-450 reductase-deficient strain. Gene 142(1):123-7 SGD PMID 8181746

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