YNL068C

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Systematic name YNL068C
Gene name FKH2
Aliases
Feature type ORF, Verified
Coordinates Chr XIV:498290..495702
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Description of YNL068C: Forkhead family transcription factor with a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase[1][2][3][4][5][6][7]



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References

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  1. Pic-Taylor A, et al. (2004) Regulation of cell cycle-specific gene expression through cyclin-dependent kinase-mediated phosphorylation of the forkhead transcription factor Fkh2p. Mol Cell Biol 24(22):10036-46 SGD PMID 15509804
  2. Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
  3. Morillon A, et al. (2003) Regulation of elongating RNA polymerase II by forkhead transcription factors in yeast. Science 300(5618):492-5 SGD PMID 12702877
  4. Hollenhorst PC, et al. (2001) Mechanisms controlling differential promoter-occupancy by the yeast forkhead proteins Fkh1p and Fkh2p: implications for regulating the cell cycle and differentiation. Genes Dev 15(18):2445-56 SGD PMID 11562353
  5. Kumar R, et al. (2000) Forkhead transcription factors, Fkh1p and Fkh2p, collaborate with Mcm1p to control transcription required for M-phase. Curr Biol 10(15):896-906 SGD PMID 10959837
  6. Zhu G, et al. (2000) Two yeast forkhead genes regulate the cell cycle and pseudohyphal growth. Nature 406(6791):90-4 SGD PMID 10894548
  7. Hollenhorst PC, et al. (2000) Forkhead genes in transcriptional silencing, cell morphology and the cell cycle. Overlapping and distinct functions for FKH1 and FKH2 in Saccharomyces cerevisiae. Genetics 154(4):1533-48 SGD PMID 10747051

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