Difference between revisions of "YML097C"

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'''Description of YML097C:''' A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin<ref name='S000046430'>Hama H, et al. (1999) Vps9p is a guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport. J Biol Chem 274(21):15284-91 {{SGDpaper|S000046430}} PMID 10329739</ref><ref name='S000046859'>Burd CG, et al. (1996) A yeast protein related to a mammalian Ras-binding protein, Vps9p, is required for localization of vacuolar proteins. Mol Cell Biol 16(5):2369-77 {{SGDpaper|S000046859}} PMID 8628304</ref><ref name='S000073618'>Davies BA, et al. (2003) Vps9p CUE domain ubiquitin binding is required for efficient endocytic protein traffic. J Biol Chem 278(22):19826-33
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'''Description of YML097C:''' A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin<ref name='S000046859'>Burd CG, et al. (1996) A yeast protein related to a mammalian Ras-binding protein, Vps9p, is required for localization of vacuolar proteins. Mol Cell Biol 16(5):2369-77 {{SGDpaper|S000046859}} PMID 8628304</ref><ref name='S000073618'>Davies BA, et al. (2003) Vps9p CUE domain ubiquitin binding is required for efficient endocytic protein traffic. J Biol Chem 278(22):19826-33 {{SGDpaper|S000073618}} PMID 12654912</ref><ref name='S000046430'>Hama H, et al. (1999) Vps9p is a guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport. J Biol Chem 274(21):15284-91
  {{SGDpaper|S000073618}} PMID 12654912</ref>
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  {{SGDpaper|S000046430}} PMID 10329739</ref>
 
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Revision as of 14:05, 25 February 2010

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Systematic name YML097C
Gene name VPS9
Aliases VPL31, VPT9
Feature type ORF, Verified
Coordinates Chr XIII:79690..78335
Primary SGDID S000004563


Description of YML097C: A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin[1][2][3]




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References

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  1. Burd CG, et al. (1996) A yeast protein related to a mammalian Ras-binding protein, Vps9p, is required for localization of vacuolar proteins. Mol Cell Biol 16(5):2369-77 SGD PMID 8628304
  2. Davies BA, et al. (2003) Vps9p CUE domain ubiquitin binding is required for efficient endocytic protein traffic. J Biol Chem 278(22):19826-33 SGD PMID 12654912
  3. Hama H, et al. (1999) Vps9p is a guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport. J Biol Chem 274(21):15284-91 SGD PMID 10329739

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