YML061C

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Systematic name YML061C
Gene name PIF1
Aliases TST1
Feature type ORF, Verified
Coordinates Chr XIII:151532..148953
Primary SGDID S000004526


Description of YML061C: DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells[1][2][3][4][5][6]




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Community Commentary

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DNA and RNA Details

Other DNA and RNA Details

Other Topic: expression

Specifically lower expression in carbon limited chemostat cultures versus carbon excess. [7] [8]





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References

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  1. Crider DG, et al. (2012) Rad53 is essential for a mitochondrial DNA inheritance checkpoint regulating G1 to S progression. J Cell Biol () SGD PMID 22927468
  2. Foury F and Lahaye A (1987) Cloning and sequencing of the PIF gene involved in repair and recombination of yeast mitochondrial DNA. EMBO J 6(5):1441-9 SGD PMID 3038524
  3. Guirola M, et al. (2010) Lack of DNA helicase Pif1 disrupts zinc and iron homoeostasis in yeast. Biochem J 432(3):595-605 SGD PMID 20858222
  4. Ivessa AS, et al. (2000) The Saccharomyces Pif1p DNA helicase and the highly related Rrm3p have opposite effects on replication fork progression in ribosomal DNA. Cell 100(4):479-89 SGD PMID 10693764
  5. Vega LR, et al. (2007) Sensitivity of yeast strains with long g-tails to levels of telomere-bound telomerase. PLoS Genet 3(6):e105 SGD PMID 17590086
  6. Zhou J, et al. (2000) Pif1p helicase, a catalytic inhibitor of telomerase in yeast. Science 289(5480):771-4 SGD PMID 10926538
  7. Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. J Biol Chem 278(5):3265-74 SGD PMID 12414795
  8. submitted by Viktor Boer on 2003-07-25

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