Difference between revisions of "YLR186W"
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| − | '''Description of YLR186W:''' Member of the alpha/beta knot fold methyltransferase superfamily; required for maturation of 18S rRNA and for 40S ribosome production; interacts with RNA and with S-adenosylmethionine; associates with spindle/microtubules; forms homodimers<ref name='S000069531'>Eschrich D, et al. (2002) Nep1p (Emg1p), a novel protein conserved in eukaryotes and archaea, is involved in ribosome biogenesis. Curr Genet 40(5):326-38 {{SGDpaper|S000069531}} PMID 11935223</ref><ref name='S000124903'>Leulliot N, et al. (2008) The yeast ribosome synthesis factor Emg1 is a novel member of the superfamily of alpha/beta knot fold methyltransferases. Nucleic Acids Res 36(2):629-39 {{SGDpaper|S000124903}} PMID 18063569</ref><ref name='S000066272'>Liu PC and Thiele DJ (2001) Novel stress-responsive genes EMG1 and NOP14 encode conserved, interacting proteins required for 40S ribosome biogenesis. Mol Biol Cell 12(11):3644-57 {{SGDpaper|S000066272}} PMID 11694595</ref><ref name='S000074191'>Samanta MP and Liang S (2003) Predicting protein functions from redundancies in large-scale protein interaction networks. Proc Natl Acad Sci U S A 100(22):12579-83 | + | '''Description of YLR186W:''' Member of the alpha/beta knot fold methyltransferase superfamily; required for maturation of 18S rRNA and for 40S ribosome production; interacts with RNA and with S-adenosylmethionine; associates with spindle/microtubules; forms homodimers; human ortholog is mutated in Bowen-Conradi syndrome<ref name='S000150432'>Armistead J, et al. (2009) Mutation of a gene essential for ribosome biogenesis, EMG1, causes Bowen-Conradi syndrome. Am J Hum Genet 84(6):728-39 {{SGDpaper|S000150432}} PMID 19463982</ref><ref name='S000069531'>Eschrich D, et al. (2002) Nep1p (Emg1p), a novel protein conserved in eukaryotes and archaea, is involved in ribosome biogenesis. Curr Genet 40(5):326-38 {{SGDpaper|S000069531}} PMID 11935223</ref><ref name='S000124903'>Leulliot N, et al. (2008) The yeast ribosome synthesis factor Emg1 is a novel member of the superfamily of alpha/beta knot fold methyltransferases. Nucleic Acids Res 36(2):629-39 {{SGDpaper|S000124903}} PMID 18063569</ref><ref name='S000066272'>Liu PC and Thiele DJ (2001) Novel stress-responsive genes EMG1 and NOP14 encode conserved, interacting proteins required for 40S ribosome biogenesis. Mol Biol Cell 12(11):3644-57 {{SGDpaper|S000066272}} PMID 11694595</ref><ref name='S000074191'>Samanta MP and Liang S (2003) Predicting protein functions from redundancies in large-scale protein interaction networks. Proc Natl Acad Sci U S A 100(22):12579-83 |
{{SGDpaper|S000074191}} PMID 14566057</ref> | {{SGDpaper|S000074191}} PMID 14566057</ref> | ||
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Revision as of 14:05, 10 August 2012
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| Systematic name | YLR186W |
| Gene name | EMG1 |
| Aliases | NEP1 |
| Feature type | ORF, Verified |
| Coordinates | Chr XII:523632..524390 |
| Primary SGDID | S000004176 |
Description of YLR186W: Member of the alpha/beta knot fold methyltransferase superfamily; required for maturation of 18S rRNA and for 40S ribosome production; interacts with RNA and with S-adenosylmethionine; associates with spindle/microtubules; forms homodimers; human ortholog is mutated in Bowen-Conradi syndrome[1][2][3][4][5]
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References
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- ↑ Armistead J, et al. (2009) Mutation of a gene essential for ribosome biogenesis, EMG1, causes Bowen-Conradi syndrome. Am J Hum Genet 84(6):728-39 SGD PMID 19463982
- ↑ Eschrich D, et al. (2002) Nep1p (Emg1p), a novel protein conserved in eukaryotes and archaea, is involved in ribosome biogenesis. Curr Genet 40(5):326-38 SGD PMID 11935223
- ↑ Leulliot N, et al. (2008) The yeast ribosome synthesis factor Emg1 is a novel member of the superfamily of alpha/beta knot fold methyltransferases. Nucleic Acids Res 36(2):629-39 SGD PMID 18063569
- ↑ Liu PC and Thiele DJ (2001) Novel stress-responsive genes EMG1 and NOP14 encode conserved, interacting proteins required for 40S ribosome biogenesis. Mol Biol Cell 12(11):3644-57 SGD PMID 11694595
- ↑ Samanta MP and Liang S (2003) Predicting protein functions from redundancies in large-scale protein interaction networks. Proc Natl Acad Sci U S A 100(22):12579-83 SGD PMID 14566057
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