YLR117C

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Systematic name YLR117C
Gene name CLF1
Aliases NTC77, SYF3
Feature type ORF, Verified
Coordinates Chr XII:384535..382472


Description of YLR117C: Essential splicesome assembly factor; contains multiple tetratricopeptide repeat (TPR) protein-binding motifs and interacts specifically with many spliceosome components, may serve as a scaffold during splicesome assembly[1][2][3][4]




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References

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  1. Wang Q, et al. (2003) The Clf1p splicing factor promotes spliceosome assembly through N-terminal tetratricopeptide repeat contacts. J Biol Chem 278(10):7875-83 SGD PMID 12509417
  2. Vincent K, et al. (2003) Genetic interactions with CLF1 identify additional pre-mRNA splicing factors and a link between activators of yeast vesicular transport and splicing. Genetics 164(3):895-907 SGD PMID 12871902
  3. Ben-Yehuda S, et al. (2000) Genetic and physical interactions between factors involved in both cell cycle progression and pre-mRNA splicing in Saccharomyces cerevisiae. Genetics 156(4):1503-17 SGD PMID 11102353
  4. Chung S, et al. (1999) Yeast ortholog of the Drosophila crooked neck protein promotes spliceosome assembly through stable U4/U6.U5 snRNP addition. RNA 5(8):1042-54 SGD PMID 10445879

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