Difference between revisions of "YIR033W"

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'''Description of YIR033W:''' ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting<ref name='S000073474'>Shcherbik N, et al. (2003) Rsp5p is required for ER bound Mga2p120 polyubiquitination and release of the processed/tethered transactivator Mga2p90. Curr Biol 13(14):1227-33 {{SGDpaper|S000073474}} PMID 12867034</ref><ref name='S000066217'>Chellappa R, et al. (2001) The membrane proteins, Spt23p and Mga2p, play distinct roles in the activation of Saccharomyces cerevisiae OLE1 gene expression. Fatty acid-mediated regulation of Mga2p activity is independent of its proteolytic processing into a soluble transcription activator. J Biol Chem 276(47):43548-56
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'''Description of YIR033W:''' ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting<ref name='S000066217'>Chellappa R, et al. (2001) The membrane proteins, Spt23p and Mga2p, play distinct roles in the activation of Saccharomyces cerevisiae OLE1 gene expression. Fatty acid-mediated regulation of Mga2p activity is independent of its proteolytic processing into a soluble transcription activator. J Biol Chem 276(47):43548-56 {{SGDpaper|S000066217}} PMID 11557770</ref><ref name='S000073474'>Shcherbik N, et al. (2003) Rsp5p is required for ER bound Mga2p120 polyubiquitination and release of the processed/tethered transactivator Mga2p90. Curr Biol 13(14):1227-33
  {{SGDpaper|S000066217}} PMID 11557770</ref>
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  {{SGDpaper|S000073474}} PMID 12867034</ref>
 
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Revision as of 14:05, 31 March 2009

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Systematic name YIR033W
Gene name MGA2
Aliases
Feature type ORF, Verified
Coordinates Chr IX:416121..419462
Primary SGDID S000001472


Description of YIR033W: ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting[1][2]




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References

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  1. Chellappa R, et al. (2001) The membrane proteins, Spt23p and Mga2p, play distinct roles in the activation of Saccharomyces cerevisiae OLE1 gene expression. Fatty acid-mediated regulation of Mga2p activity is independent of its proteolytic processing into a soluble transcription activator. J Biol Chem 276(47):43548-56 SGD PMID 11557770
  2. Shcherbik N, et al. (2003) Rsp5p is required for ER bound Mga2p120 polyubiquitination and release of the processed/tethered transactivator Mga2p90. Curr Biol 13(14):1227-33 SGD PMID 12867034

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