Difference between revisions of "YHR079C"
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| − | '''Description of YHR079C:''' Serine-threonine kinase and endoribonuclease; transmembrane protein that | + | '''Description of YHR079C:''' Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress<ref name='S000059115'>Okamura K, et al. (2000) Dissociation of Kar2p/BiP from an ER sensory molecule, Ire1p, triggers the unfolded protein response in yeast. Biochem Biophys Res Commun 279(2):445-50 {{SGDpaper|S000059115}} PMID 11118306</ref><ref name='S000057870'>Welihinda AA and Kaufman RJ (1996) The unfolded protein response pathway in Saccharomyces cerevisiae. Oligomerization and trans-phosphorylation of Ire1p (Ern1p) are required for kinase activation. J Biol Chem 271(30):18181-7 {{SGDpaper|S000057870}} PMID 8663458</ref><ref name='S000046401'>Sidrauski C and Walter P (1997) The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response. Cell 90(6):1031-9 |
{{SGDpaper|S000046401}} PMID 9323131</ref> | {{SGDpaper|S000046401}} PMID 9323131</ref> | ||
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Revision as of 14:05, 10 May 2007
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| Systematic name | YHR079C |
| Gene name | IRE1 |
| Aliases | ERN1 |
| Feature type | ORF, Verified |
| Coordinates | Chr VIII:261593..258246 |
| Primary SGDID | S000001121 |
Description of YHR079C: Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress[1][2][3]
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References
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- ↑ Okamura K, et al. (2000) Dissociation of Kar2p/BiP from an ER sensory molecule, Ire1p, triggers the unfolded protein response in yeast. Biochem Biophys Res Commun 279(2):445-50 SGD PMID 11118306
- ↑ Welihinda AA and Kaufman RJ (1996) The unfolded protein response pathway in Saccharomyces cerevisiae. Oligomerization and trans-phosphorylation of Ire1p (Ern1p) are required for kinase activation. J Biol Chem 271(30):18181-7 SGD PMID 8663458
- ↑ Sidrauski C and Walter P (1997) The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response. Cell 90(6):1031-9 SGD PMID 9323131
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