Difference between revisions of "YGR198W"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YGR198W YGR198W]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003430 YGR198W]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''YPP1 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''YPP1 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr VII:894698..897151
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|nowrap| Chr VII:894693..897146
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000003430
 
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'''Description of {{PAGENAME}}:''' Cargo-transport protein involved in endocytosis; may interact with ribosomes, based on co-purification experiments; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene<ref name='S000119076'>Flower T, et al. (2006) The Yeast Endocytosis Gene YGR198w (YPP1) Suppresses A30P Alpha-Synuclein Toxicity Nat Cell Biol () {{SGDpaper|S000119076}} PMID </ref><ref name='S000115662'>Fleischer TC, et al. (2006) Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Genes Dev 20(10):1294-307 {{SGDpaper|S000115662}} PMID 16702403</ref><ref name='S000074185'>Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 {{SGDpaper|S000074185}} PMID 14562095</ref><ref name='S000047842'>Rodriguez-Pena JM, et al. (1998) The deletion of six ORFs of unknown function from Saccharomyces cerevisiae chromosome VII reveals two essential genes: YGR195w and YGR198w. Yeast 14(9):853-60
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'''Description of YGR198W:''' Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene<ref name='S000123065'>Flower TR, et al. (2007) YGR198w (YPP1) targets A30P alpha-synuclein to the vacuole for degradation. J Cell Biol 177(6):1091-104 {{SGDpaper|S000123065}} PMID 17576801</ref><ref name='S000074185'>Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 {{SGDpaper|S000074185}} PMID 14562095</ref><ref name='S000047842'>Rodriguez-Pena JM, et al. (1998) The deletion of six ORFs of unknown function from Saccharomyces cerevisiae chromosome VII reveals two essential genes: YGR195w and YGR198w. Yeast 14(9):853-60 {{SGDpaper|S000047842}} PMID 9818723</ref><ref name='S000126928'>Zhai C, et al. (2008) Ypp1/YGR198w plays an essential role in phosphoinositide signalling at the plasma membrane. Biochem J 415(3):455-66
  {{SGDpaper|S000047842}} PMID 9818723</ref>
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  {{SGDpaper|S000126928}} PMID 18601652</ref>
 
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GFP-tag is more effective at the n-terminal end. Adding an epitope tag at the C-terminus makes the strain somewhat sick and lowers PI4P levels, however, it seems to localize correctly.
  
  
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==References==
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==References==
 
==References==

Latest revision as of 07:45, 23 January 2012

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Systematic name YGR198W
Gene name YPP1
Aliases
Feature type ORF, Verified
Coordinates Chr VII:894693..897146
Primary SGDID S000003430


Description of YGR198W: Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene[1][2][3][4]




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Community Commentary

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GFP-tag is more effective at the n-terminal end. Adding an epitope tag at the C-terminus makes the strain somewhat sick and lowers PI4P levels, however, it seems to localize correctly.



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References

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  1. Flower TR, et al. (2007) YGR198w (YPP1) targets A30P alpha-synuclein to the vacuole for degradation. J Cell Biol 177(6):1091-104 SGD PMID 17576801
  2. Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 SGD PMID 14562095
  3. Rodriguez-Pena JM, et al. (1998) The deletion of six ORFs of unknown function from Saccharomyces cerevisiae chromosome VII reveals two essential genes: YGR195w and YGR198w. Yeast 14(9):853-60 SGD PMID 9818723
  4. Zhai C, et al. (2008) Ypp1/YGR198w plays an essential role in phosphoinositide signalling at the plasma membrane. Biochem J 415(3):455-66 SGD PMID 18601652

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References

See Help:References on how to add references

See Help:Categories on how to add the wiki page for this gene to a Category </protect>