Difference between revisions of "YGR181W"

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'''Description of YGR181W:''' Mitochondrial intermembrane space protein, forms a complex with Tim8p that mediates import and insertion of a subset of polytopic inner membrane proteins; may prevent aggregation of incoming proteins in a chaperone-like manner<ref name='S000064131'>Kurz M, et al. (1999) Biogenesis of Tim proteins of the mitochondrial carrier import pathway: differential targeting mechanisms and crossing over with the main import pathway. Mol Biol Cell 10(7):2461-74 {{SGDpaper|S000064131}} PMID 10397776</ref><ref name='S000071489'>Curran SP, et al. (2002) The role of the Tim8p-Tim13p complex in a conserved import pathway for mitochondrial polytopic inner membrane proteins. J Cell Biol 158(6):1017-27
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'''Description of YGR181W:''' Mitochondrial intermembrane space protein, forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane<ref name='S000043156'>Koehler CM, et al. (1999) Human deafness dystonia syndrome is a mitochondrial disease. Proc Natl Acad Sci U S A 96(5):2141-6 {{SGDpaper|S000043156}} PMID 10051608</ref><ref name='S000047441'>Leuenberger D, et al. (1999) Different import pathways through the mitochondrial intermembrane space for inner membrane proteins. EMBO J 18(17):4816-22 {{SGDpaper|S000047441}} PMID 10469659</ref><ref name='S000064131'>Kurz M, et al. (1999) Biogenesis of Tim proteins of the mitochondrial carrier import pathway: differential targeting mechanisms and crossing over with the main import pathway. Mol Biol Cell 10(7):2461-74 {{SGDpaper|S000064131}} PMID 10397776</ref><ref name='S000071489'>Curran SP, et al. (2002) The role of the Tim8p-Tim13p complex in a conserved import pathway for mitochondrial polytopic inner membrane proteins. J Cell Biol 158(6):1017-27 {{SGDpaper|S000071489}} PMID 12221072</ref><ref name='S000131707'>Davis AJ, et al. (2007) The Tim9p/10p and Tim8p/13p complexes bind to specific sites on Tim23p during mitochondrial protein import. Mol Biol Cell 18(2):475-86
  {{SGDpaper|S000071489}} PMID 12221072</ref>
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  {{SGDpaper|S000131707}} PMID 17122363</ref>
 
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Revision as of 14:05, 21 October 2009

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Systematic name YGR181W
Gene name TIM13
Aliases
Feature type ORF, Verified
Coordinates Chr VII:858292..858609
Primary SGDID S000003413


Description of YGR181W: Mitochondrial intermembrane space protein, forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane[1][2][3][4][5]




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References

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  1. Koehler CM, et al. (1999) Human deafness dystonia syndrome is a mitochondrial disease. Proc Natl Acad Sci U S A 96(5):2141-6 SGD PMID 10051608
  2. Leuenberger D, et al. (1999) Different import pathways through the mitochondrial intermembrane space for inner membrane proteins. EMBO J 18(17):4816-22 SGD PMID 10469659
  3. Kurz M, et al. (1999) Biogenesis of Tim proteins of the mitochondrial carrier import pathway: differential targeting mechanisms and crossing over with the main import pathway. Mol Biol Cell 10(7):2461-74 SGD PMID 10397776
  4. Curran SP, et al. (2002) The role of the Tim8p-Tim13p complex in a conserved import pathway for mitochondrial polytopic inner membrane proteins. J Cell Biol 158(6):1017-27 SGD PMID 12221072
  5. Davis AJ, et al. (2007) The Tim9p/10p and Tim8p/13p complexes bind to specific sites on Tim23p during mitochondrial protein import. Mol Biol Cell 18(2):475-86 SGD PMID 17122363

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