Difference between revisions of "YGL175C"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YGL175C YGL175C]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003143 YGL175C]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''SAE2 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''SAE2 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr VII:174328..173291
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|nowrap| Chr VII:174322..173285
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000003143
 
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'''Description of {{PAGENAME}}:''' Protein with a role in accurate meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents<ref name='S000076515'>Baroni E, et al. (2004) The functions of budding yeast Sae2 in the DNA damage response require Mec1- and Tel1-dependent phosphorylation. Mol Cell Biol 24(10):4151-65 {{SGDpaper|S000076515}} PMID 15121837</ref><ref name='S000060386'>Rattray AJ, et al. (2001) Fidelity of mitotic double-strand-break repair in Saccharomyces cerevisiae: a role for SAE2/COM1. Genetics 158(1):109-22 {{SGDpaper|S000060386}} PMID 11333222</ref><ref name='S000045010'>McKee AH and Kleckner N (1997) Mutations in Saccharomyces cerevisiae that block meiotic prophase chromosome metabolism and confer cell cycle arrest at pachytene identify two new meiosis-specific genes SAE1 and SAE3. Genetics 146(3):817-34 {{SGDpaper|S000045010}} PMID 9215889</ref><ref name='S000045008'>McKee AH and Kleckner N (1997) A general method for identifying recessive diploid-specific mutations in Saccharomyces cerevisiae, its application to the isolation of mutants blocked at intermediate stages of meiotic prophase and characterization of a new gene SAE2. Genetics 146(3):797-816 {{SGDpaper|S000045008}} PMID 9215888</ref><ref name='S000045005'>Prinz S, et al. (1997) Isolation of COM1, a new gene required to complete meiotic double-strand break-induced recombination in Saccharomyces cerevisiae. Genetics 146(3):781-95
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'''Description of YGL175C:''' Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents<ref name='S000076515'>Baroni E, et al. (2004) The functions of budding yeast Sae2 in the DNA damage response require Mec1- and Tel1-dependent phosphorylation. Mol Cell Biol 24(10):4151-65 {{SGDpaper|S000076515}} PMID 15121837</ref><ref name='S000124863'>Lengsfeld BM, et al. (2007) Sae2 Is an Endonuclease that Processes Hairpin DNA Cooperatively with the Mre11/Rad50/Xrs2 Complex. Mol Cell 28(4):638-51 {{SGDpaper|S000124863}} PMID 18042458</ref><ref name='S000045008'>McKee AH and Kleckner N (1997) A general method for identifying recessive diploid-specific mutations in Saccharomyces cerevisiae, its application to the isolation of mutants blocked at intermediate stages of meiotic prophase and characterization of a new gene SAE2. Genetics 146(3):797-816 {{SGDpaper|S000045008}} PMID 9215888</ref><ref name='S000045005'>Prinz S, et al. (1997) Isolation of COM1, a new gene required to complete meiotic double-strand break-induced recombination in Saccharomyces cerevisiae. Genetics 146(3):781-95 {{SGDpaper|S000045005}} PMID 9215887</ref><ref name='S000060386'>Rattray AJ, et al. (2001) Fidelity of mitotic double-strand-break repair in Saccharomyces cerevisiae: a role for SAE2/COM1. Genetics 158(1):109-22
  {{SGDpaper|S000045005}} PMID 9215887</ref>
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  {{SGDpaper|S000060386}} PMID 11333222</ref>
 
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==Community Commentary==
 
==Community Commentary==
 
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<!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation -->
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<!--
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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Latest revision as of 07:45, 23 January 2012

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Systematic name YGL175C
Gene name SAE2
Aliases COM1
Feature type ORF, Verified
Coordinates Chr VII:174322..173285
Primary SGDID S000003143


Description of YGL175C: Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents[1][2][3][4][5]




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References

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  1. Baroni E, et al. (2004) The functions of budding yeast Sae2 in the DNA damage response require Mec1- and Tel1-dependent phosphorylation. Mol Cell Biol 24(10):4151-65 SGD PMID 15121837
  2. Lengsfeld BM, et al. (2007) Sae2 Is an Endonuclease that Processes Hairpin DNA Cooperatively with the Mre11/Rad50/Xrs2 Complex. Mol Cell 28(4):638-51 SGD PMID 18042458
  3. McKee AH and Kleckner N (1997) A general method for identifying recessive diploid-specific mutations in Saccharomyces cerevisiae, its application to the isolation of mutants blocked at intermediate stages of meiotic prophase and characterization of a new gene SAE2. Genetics 146(3):797-816 SGD PMID 9215888
  4. Prinz S, et al. (1997) Isolation of COM1, a new gene required to complete meiotic double-strand break-induced recombination in Saccharomyces cerevisiae. Genetics 146(3):781-95 SGD PMID 9215887
  5. Rattray AJ, et al. (2001) Fidelity of mitotic double-strand-break repair in Saccharomyces cerevisiae: a role for SAE2/COM1. Genetics 158(1):109-22 SGD PMID 11333222

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