Difference between revisions of "YER070W"

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'''Description of YER070W:''' One of two large regulatory subunits of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits<ref name='S000046920'>Elledge SJ and Davis RW (1990) Two genes differentially regulated in the cell cycle and by DNA-damaging agents encode alternative regulatory subunits of ribonucleotide reductase. Genes Dev 4(5):740-51 {{SGDpaper|S000046920}} PMID 2199320</ref><ref name='S000073212'>Yao R, et al. (2003) Subcellular localization of yeast ribonucleotide reductase regulated by the DNA replication and damage checkpoint pathways. Proc Natl Acad Sci U S A 100(11):6628-33
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'''Description of YER070W:''' Major isoform of the large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits<ref name='S000046920'>Elledge SJ and Davis RW (1990) Two genes differentially regulated in the cell cycle and by DNA-damaging agents encode alternative regulatory subunits of ribonucleotide reductase. Genes Dev 4(5):740-51 {{SGDpaper|S000046920}} PMID 2199320</ref><ref name='S000073212'>Yao R, et al. (2003) Subcellular localization of yeast ribonucleotide reductase regulated by the DNA replication and damage checkpoint pathways. Proc Natl Acad Sci U S A 100(11):6628-33
 
  {{SGDpaper|S000073212}} PMID 12732713</ref>
 
  {{SGDpaper|S000073212}} PMID 12732713</ref>
 
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Revision as of 14:05, 15 September 2010

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Systematic name YER070W
Gene name RNR1
Aliases CRT7, RIR1, SDS12
Feature type ORF, Verified
Coordinates Chr V:298948..301614
Primary SGDID S000000872


Description of YER070W: Major isoform of the large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits[1][2]




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References

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  1. Elledge SJ and Davis RW (1990) Two genes differentially regulated in the cell cycle and by DNA-damaging agents encode alternative regulatory subunits of ribonucleotide reductase. Genes Dev 4(5):740-51 SGD PMID 2199320
  2. Yao R, et al. (2003) Subcellular localization of yeast ribonucleotide reductase regulated by the DNA replication and damage checkpoint pathways. Proc Natl Acad Sci U S A 100(11):6628-33 SGD PMID 12732713

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