Difference between revisions of "YER048W-A"
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| − | '''Description of YER048W-A:''' | + | '''Description of YER048W-A:''' Cysteine desulfurase (Nfs1p) activator; essential for the formation of the persulfide intermediate at the desulfurase active site during pyridoxal phosphate-dependent desulfuration of cysteine; required for mitochondrial iron-sulfur cluster biosynthesis<ref name='S000113860'>Adam AC, et al. (2006) The Nfs1 interacting protein Isd11 has an essential role in Fe/S cluster biogenesis in mitochondria. EMBO J 25(1):174-83 {{SGDpaper|S000113860}} PMID 16341090</ref><ref name='S000146765'>Pandey A, et al. (2011) Isd11p activates the mitochondrial cysteine desulfurase, Nfs1p. J Biol Chem () {{SGDpaper|S000146765}} PMID 21908622</ref><ref name='S000120450'>Wiedemann N, et al. (2006) Essential role of Isd11 in mitochondrial iron-sulfur cluster synthesis on Isu scaffold proteins. EMBO J 25(1):184-95 |
{{SGDpaper|S000120450}} PMID 16341089</ref> | {{SGDpaper|S000120450}} PMID 16341089</ref> | ||
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Revision as of 14:05, 26 September 2011
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| Systematic name | YER048W-A |
| Gene name | ISD11 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr V:250718..251002 |
| Primary SGDID | S000007237 |
Description of YER048W-A: Cysteine desulfurase (Nfs1p) activator; essential for the formation of the persulfide intermediate at the desulfurase active site during pyridoxal phosphate-dependent desulfuration of cysteine; required for mitochondrial iron-sulfur cluster biosynthesis[1][2][3]
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Contents
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References
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- ↑ Adam AC, et al. (2006) The Nfs1 interacting protein Isd11 has an essential role in Fe/S cluster biogenesis in mitochondria. EMBO J 25(1):174-83 SGD PMID 16341090
- ↑ Pandey A, et al. (2011) Isd11p activates the mitochondrial cysteine desulfurase, Nfs1p. J Biol Chem () SGD PMID 21908622
- ↑ Wiedemann N, et al. (2006) Essential role of Isd11 in mitochondrial iron-sulfur cluster synthesis on Isu scaffold proteins. EMBO J 25(1):184-95 SGD PMID 16341089
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