Difference between revisions of "YDR390C"

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'''Description of YDR390C:''' Nuclear protein that acts as a heterodimer with Aos1p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability<ref name='S000039750'>Dohmen RJ, et al. (1995) An essential yeast gene encoding a homolog of ubiquitin-activating enzyme. J Biol Chem 270(30):18099-109 {{SGDpaper|S000039750}} PMID 7629121</ref><ref name='S000040819'>Johnson ES, et al. (1997) The ubiquitin-like protein Smt3p is activated for conjugation to other proteins by an Aos1p/Uba2p heterodimer. EMBO J 16(18):5509-19
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'''Description of YDR390C:''' Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability<ref name='S000039750'>Dohmen RJ, et al. (1995) An essential yeast gene encoding a homolog of ubiquitin-activating enzyme. J Biol Chem 270(30):18099-109 {{SGDpaper|S000039750}} PMID 7629121</ref><ref name='S000040819'>Johnson ES, et al. (1997) The ubiquitin-like protein Smt3p is activated for conjugation to other proteins by an Aos1p/Uba2p heterodimer. EMBO J 16(18):5509-19
 
  {{SGDpaper|S000040819}} PMID 9312010</ref>
 
  {{SGDpaper|S000040819}} PMID 9312010</ref>
 
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Revision as of 14:05, 7 July 2010

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Systematic name YDR390C
Gene name UBA2
Aliases UAL1
Feature type ORF, Verified
Coordinates Chr IV:1256840..1254930
Primary SGDID S000002798


Description of YDR390C: Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability[1][2]




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References

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  1. Dohmen RJ, et al. (1995) An essential yeast gene encoding a homolog of ubiquitin-activating enzyme. J Biol Chem 270(30):18099-109 SGD PMID 7629121
  2. Johnson ES, et al. (1997) The ubiquitin-like protein Smt3p is activated for conjugation to other proteins by an Aos1p/Uba2p heterodimer. EMBO J 16(18):5509-19 SGD PMID 9312010

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