YDL044C
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| Systematic name | YDL044C |
| Gene name | MTF2 |
| Aliases | NAM1 |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:375286..373964 |
Description of YDL044C: Mitochondrial matrix protein that interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription[1][2][3]
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Community Commentary
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Interactions
Genetic
YDL044C is suppressed by SLS1
Strain Background: DBY2006
Genotype: ACB1
Mutation type(s): null
The mitochondrial membrane protein Sls1p suppresses the petite phenotype of mtRNA polymerase (Rpo41p) amino-terminal domain and a mtf2/nam1 null mutations, indicating that transcription and tranlation of mtDNA-encoded genes occurs coordinately at the inner mitochondrial membrane. [4] [5]
Two Hybrid
Two Hybrid interaction with RPO41
The mitochondrial matrix protein Mtf2p/Nam1p interacts with the amino-terminal domain of mtRNA polymerase (Rpo41p) to couple post-transcriptional events to transcription during mitochondrial gene expression. [1] [5]
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References
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- ↑ 1.0 1.1 Rodeheffer MS, et al. (2001) Nam1p, a protein involved in RNA processing and translation, is coupled to transcription through an interaction with yeast mitochondrial RNA polymerase. J Biol Chem 276(11):8616-22 SGD PMID 11118450
- ↑ Asher EB, et al. (1989) Novel class of nuclear genes involved in both mRNA splicing and protein synthesis in Saccharomyces cerevisiae mitochondria. Mol Gen Genet 215(3):517-28 SGD PMID 2651895
- ↑ Wallis MG, et al. (1994) The NAM1 protein (NAM1p), which is selectively required for cox1, cytb and atp6 transcript processing/stabilisation, is located in the yeast mitochondrial matrix. Eur J Biochem 222(1):27-32 SGD PMID 8200349
- ↑ Bryan AC, et al. (2002) Sls1p is a membrane-bound regulator of transcription-coupled processes involved in Saccharomyces cerevisiae mitochondrial gene expression. Genetics 160(1):75-82 SGD PMID 11805046
- ↑ 5.0 5.1 submitted by Gerald Shadel on 2003-06-05
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