YAL034W-A
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| Systematic name | YAL034W-A | |
| Gene name | MTW1 | |
| Aliases | DSN3, NSL2 | |
| Feature type | ORF, Verified | |
| Coordinates | Chr I:79719..80588 | |
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Description of YAL034W-A: Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly[1]
Alleles, Strains, and Phenotypes
Point Mutation
Allele: mtw1-1
Strain Background: W303
Phenotype(s): Temperature(Heat) Sensitive
mtw1-1 mutants activate the spindle checkpoint in an IPL1 dependent manner. [2] [3]
Allele: mtw1-1
Strain Background: W303
Phenotype(s): Temperature(Heat) Sensitive
mtw1-1 mutants have unattached chromosomes. [2] [3]
Interactions
Genetic
YAL034W-A is suppressed by DSN1
Strain Background: W303
DSN1 is a high copy suppressor of the mtw1-1 mutant. [2] [3]
Physical
Physical interaction with CSE4
Cse4p co-immunoprecipitates with Mtw1p. [2] [3]
Physical interaction with DSN1
Mtw1p co-immunoprecipitates Dsn1p. [2] [3]
Contents
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Alleles, Strains, and Phenotypes
Point Mutation
Allele: mtw1-1
Strain Background: W303
Phenotype(s): Temperature(Heat) Sensitive
mtw1-1 mutants activate the spindle checkpoint in an IPL1 dependent manner. [2] [3]
Allele: mtw1-1
Strain Background: W303
Phenotype(s): Temperature(Heat) Sensitive
mtw1-1 mutants have unattached chromosomes. [2] [3]
Interactions
Genetic
YAL034W-A is suppressed by DSN1
Strain Background: W303
DSN1 is a high copy suppressor of the mtw1-1 mutant. [2] [3]
Physical
Physical interaction with CSE4
Cse4p co-immunoprecipitates with Mtw1p. [2] [3]
Physical interaction with DSN1
Mtw1p co-immunoprecipitates Dsn1p. [2] [3]
References
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- ↑ De Wulf P, et al. (2003) Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes. Genes Dev 17(23):2902-21 SGD PMID 14633972
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 Pinsky BA, et al. (2003) An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase. Dev Cell 5(5):735-45 SGD PMID 14602074
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 3.9 submitted by Benjamin Pinsky on 2004-03-04
See Help:Categories on how to add the wiki page for this gene to a Category
- ORF
- ORF, Verified
- Topic:Alleles, Strains, and Phenotypes
- Topic:Alleles, Strains, and Phenotypes:Point Mutation
- Phenotype:Temperature(Heat) Sensitive
- Topic:Interactions
- Topic:Interactions:Genetic
- Genetic Interaction with DSN1
- Topic:Interactions:Physical
- Physical Interactions with CSE4
- Physical Interactions with DSN1
