YMR217W

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Systematic name YMR217W
Gene name GUA1
Aliases
Feature type ORF, Verified
Coordinates Chr XIII:701789..703366


Description of YMR217W: GMP synthase, an enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation[1][2][3][4]




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References

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  1. Escobar-Henriques M, et al. (2003) Transcription initiation of the yeast IMD2 gene is abolished in response to nutrient limitation through a sequence in its coding region. Mol Cell Biol 23(17):6279-90 SGD PMID 12917348
  2. Gardner WJ and Woods RA (1979) Isolation and characterisation of guanine auxotrophs in Saccharomyces cerevisiae. Can J Microbiol 25(3):380-9 SGD PMID 222417
  3. Escobar-Henriques M and Daignan-Fornier B (2001) Transcriptional regulation of the yeast gmp synthesis pathway by its end products. J Biol Chem 276(2):1523-30 SGD PMID 11035032
  4. Dujardin G, et al. (1994) Cloning and sequencing of the GMP synthetase-encoding gene of Saccharomyces cerevisiae. Gene 139(1):127-32 SGD PMID 8112582

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