YNL251C
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| Systematic name | YNL251C |
| Gene name | NRD1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XIV:174315..172588 |
| Primary SGDID | S000005195 |
Description of YNL251C: RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex mediates termination of snoRNAs and cryptic unstable transcripts (CUTs); interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p), preferentially at phosphorylated Ser5; H3K4 trimethylation of transcribed regions by Set1p enhances recruitment of Nrd1p to those sites; required for 3' end maturation of nonpolyadenylated RNAs[1][2][3][4]
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References
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- ↑ Conrad NK, et al. (2000) A yeast heterogeneous nuclear ribonucleoprotein complex associated with RNA polymerase II. Genetics 154(2):557-71 SGD PMID 10655211
- ↑ Steinmetz EJ and Brow DA (1998) Control of pre-mRNA accumulation by the essential yeast protein Nrd1 requires high-affinity transcript binding and a domain implicated in RNA polymerase II association. Proc Natl Acad Sci U S A 95(12):6699-704 SGD PMID 9618475
- ↑ Terzi N, et al. (2011) H3K4 trimethylation by Set1 promotes efficient termination by the Nrd1-Nab3-Sen1 pathway. Mol Cell Biol () SGD PMID 21709022
- ↑ Vasiljeva L, et al. (2008) The Nrd1-Nab3-Sen1 termination complex interacts with the Ser5-phosphorylated RNA polymerase II C-terminal domain. Nat Struct Mol Biol 15(8):795-804 SGD PMID 18660819
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