Difference between revisions of "YGR255C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003487 YGR255C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''COQ6 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''COQ6 '' | ||
Latest revision as of 07:45, 23 January 2012
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| Systematic name | YGR255C |
| Gene name | COQ6 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr VII:1003962..1002523 |
| Primary SGDID | S000003487 |
Description of YGR255C: Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)[1][2][3]
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Contents
Community Commentary
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References
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- ↑ Gin P, et al. (2003) The Saccharomyces cerevisiae COQ6 gene encodes a mitochondrial flavin-dependent monooxygenase required for coenzyme Q biosynthesis. J Biol Chem 278(28):25308-16 SGD PMID 12721307
- ↑ Heeringa SF, et al. (2011) COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness. J Clin Invest 121(5):2013-24 SGD PMID 21540551
- ↑ Hsieh EJ, et al. (2007) Saccharomyces cerevisiae Coq9 polypeptide is a subunit of the mitochondrial coenzyme Q biosynthetic complex. Arch Biochem Biophys 463(1):19-26 SGD PMID 17391640
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