Difference between revisions of "YDR052C"
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− | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl? | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000002459 YDR052C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''DBF4 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''DBF4 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
|nowrap| Chr IV:560623..558509 | |nowrap| Chr IV:560623..558509 | ||
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+ | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000002459 | ||
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<br> | <br> | ||
− | '''Description of | + | '''Description of YDR052C:''' Regulatory subunit of Cdc7p-Dbf4p kinase complex, required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated<ref name='S000051467'>Lei M, et al. (1997) Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis. Genes Dev 11(24):3365-74 {{SGDpaper|S000051467}} PMID 9407029</ref><ref name='S000048592'>Cheng L, et al. (1999) Cell cycle regulation of DNA replication initiator factor Dbf4p. Mol Cell Biol 19(6):4270-8 |
{{SGDpaper|S000048592}} PMID 10330168</ref> | {{SGDpaper|S000048592}} PMID 10330168</ref> | ||
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J Biol Chem 278(5):3265-74</ref> | J Biol Chem 278(5):3265-74</ref> | ||
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Revision as of 08:46, 27 February 2007
Share your knowledge...Edit this entry! <protect>
Systematic name | YDR052C |
Gene name | DBF4 |
Aliases | DNA52, LSD7 |
Feature type | ORF, Verified |
Coordinates | Chr IV:560623..558509 |
Primary SGDID | S000002459 |
Description of YDR052C: Regulatory subunit of Cdc7p-Dbf4p kinase complex, required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated[1][2]
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [3] [4]
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References
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- ↑ Lei M, et al. (1997) Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis. Genes Dev 11(24):3365-74 SGD PMID 9407029
- ↑ Cheng L, et al. (1999) Cell cycle regulation of DNA replication initiator factor Dbf4p. Mol Cell Biol 19(6):4270-8 SGD PMID 10330168
- ↑ Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
- ↑ submitted by Jeff Ubersax on 2004-01-21
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