Difference between revisions of "YPL128C"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YPL128C YPL128C]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000006049 YPL128C]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''TBF1 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''TBF1 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr XVI:308220..306532
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|nowrap| Chr XVI:308221..306533
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000006049
 
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'''Description of {{PAGENAME}}:''' Telobox-containing general regulatory factor; binds to TTAGGG repeats within subtelomeric anti-silencing regions (STARs) and possibly throughout the genome and mediates their insulating capacity by blocking silent chromatin propagation<ref name='S000074974'>Bilaud T, et al. (1996) The telobox, a Myb-related telomeric DNA binding motif found in proteins from yeast, plants and human. Nucleic Acids Res 24(7):1294-303 {{SGDpaper|S000074974}} PMID 8614633</ref><ref name='S000071586'>Fourel G, et al. (2002) General regulatory factors (GRFs) as genome partitioners. J Biol Chem 277(44):41736-43 {{SGDpaper|S000071586}} PMID 12200417</ref><ref name='S000060749'>Fourel G, et al. (2001) An activation-independent role of transcription factors in insulator function. EMBO Rep 2(2):124-32 {{SGDpaper|S000060749}} PMID 11258704</ref><ref name='S000053340'>Fourel G, et al. (1999) Cohabitation of insulators and silencing elements in yeast subtelomeric regions. EMBO J 18(9):2522-37 {{SGDpaper|S000053340}} PMID 10228166</ref><ref name='S000040662'>Koering CE, et al. (2000) Identification of high affinity Tbf1p-binding sites within the budding yeast genome. Nucleic Acids Res 28(13):2519-26
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'''Description of YPL128C:''' Telobox-containing general regulatory factor; binds TTAGGG repeats within subtelomeric anti-silencing regions (STARs), blocking silent chromatin propagation; binds majority of snoRNA gene promoters, required for full snoRNA expression; caps DSB flanked by long T2AG3 repeats and blocks checkpoint activation<ref name='S000074974'>Bilaud T, et al. (1996) The telobox, a Myb-related telomeric DNA binding motif found in proteins from yeast, plants and human. Nucleic Acids Res 24(7):1294-303 {{SGDpaper|S000074974}} PMID 8614633</ref><ref name='S000053340'>Fourel G, et al. (1999) Cohabitation of insulators and silencing elements in yeast subtelomeric regions. EMBO J 18(9):2522-37 {{SGDpaper|S000053340}} PMID 10228166</ref><ref name='S000060749'>Fourel G, et al. (2001) An activation-independent role of transcription factors in insulator function. EMBO Rep 2(2):124-32 {{SGDpaper|S000060749}} PMID 11258704</ref><ref name='S000071586'>Fourel G, et al. (2002) General regulatory factors (GRFs) as genome partitioners. J Biol Chem 277(44):41736-43 {{SGDpaper|S000071586}} PMID 12200417</ref><ref name='S000040662'>Koering CE, et al. (2000) Identification of high affinity Tbf1p-binding sites within the budding yeast genome. Nucleic Acids Res 28(13):2519-26 {{SGDpaper|S000040662}} PMID 10871401</ref><ref name='S000134259'>Preti M, et al. (2010) The Telomere-Binding Protein Tbf1 Demarcates snoRNA Gene Promoters in Saccharomyces cerevisiae. Mol Cell 38(4):614-620 {{SGDpaper|S000134259}} PMID 20513435</ref><ref name='S000146921'>Ribaud V, et al. (2011) DNA-end capping by the budding yeast transcription factor and subtelomeric binding protein Tbf1.LID - 10.1038/emboj.2011.349 [doi] EMBO J ()
  {{SGDpaper|S000040662}} PMID 10871401</ref>
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  {{SGDpaper|S000146921}} PMID 21952045</ref>
 
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J Biol Chem 278(5):3265-74</ref>
 
J Biol Chem 278(5):3265-74</ref>
 
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Latest revision as of 07:45, 23 January 2012

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Systematic name YPL128C
Gene name TBF1
Aliases LPI16
Feature type ORF, Verified
Coordinates Chr XVI:308221..306533
Primary SGDID S000006049


Description of YPL128C: Telobox-containing general regulatory factor; binds TTAGGG repeats within subtelomeric anti-silencing regions (STARs), blocking silent chromatin propagation; binds majority of snoRNA gene promoters, required for full snoRNA expression; caps DSB flanked by long T2AG3 repeats and blocks checkpoint activation[1][2][3][4][5][6][7]




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References

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  1. Bilaud T, et al. (1996) The telobox, a Myb-related telomeric DNA binding motif found in proteins from yeast, plants and human. Nucleic Acids Res 24(7):1294-303 SGD PMID 8614633
  2. Fourel G, et al. (1999) Cohabitation of insulators and silencing elements in yeast subtelomeric regions. EMBO J 18(9):2522-37 SGD PMID 10228166
  3. Fourel G, et al. (2001) An activation-independent role of transcription factors in insulator function. EMBO Rep 2(2):124-32 SGD PMID 11258704
  4. Fourel G, et al. (2002) General regulatory factors (GRFs) as genome partitioners. J Biol Chem 277(44):41736-43 SGD PMID 12200417
  5. Koering CE, et al. (2000) Identification of high affinity Tbf1p-binding sites within the budding yeast genome. Nucleic Acids Res 28(13):2519-26 SGD PMID 10871401
  6. Preti M, et al. (2010) The Telomere-Binding Protein Tbf1 Demarcates snoRNA Gene Promoters in Saccharomyces cerevisiae. Mol Cell 38(4):614-620 SGD PMID 20513435
  7. Ribaud V, et al. (2011) DNA-end capping by the budding yeast transcription factor and subtelomeric binding protein Tbf1.LID - 10.1038/emboj.2011.349 [doi] EMBO J () SGD PMID 21952045

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