Difference between revisions of "YOL055C"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005416 YOL055C]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005416 YOL055C]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''THI20 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''THI20 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr XV:226074..224419
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|nowrap| Chr XV:226075..224420
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000005416
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000005416
 
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'''Description of YOL055C:''' Multifunctional protein with hydroxymethylpyrimidine phosphate (HMP-P) kinase and thiaminase activities; involved in thiamine biosynthesis and degradation; in a gene family with THI21 and THI22; HMP-P kinase activity redundant with Thi21p<ref name='S000082137'>Haas AL, et al. (2005) Thi20, a remarkable enzyme from Saccharomyces cerevisiae with dual thiamin biosynthetic and degradation activities. Bioorg Chem 33(4):338-44 {{SGDpaper|S000082137}} PMID 15967475</ref><ref name='S000056318'>Llorente B, et al. (1999) Genetic redundancy and gene fusion in the genome of the Baker's yeast Saccharomyces cerevisiae: functional characterization of a three-member gene family involved in the thiamine biosynthetic pathway. Mol Microbiol 32(6):1140-52
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'''Description of YOL055C:''' Trifunctional enzyme of thiamine biosynthesis, degradation and salvage; has hydroxymethylpyrimidine (HMP) kinase, HMP-phosphate (HMP-P) kinase and thiaminase activities; member of a gene family with THI21 and THI22; HMP and HMP-P kinase activity redundant with Thi21p<ref name='S000146614'>French JB, et al. (2011) Structure of trifunctional THI20 from yeast. Acta Crystallogr D Biol Crystallogr 67(Pt 9):784-91 {{SGDpaper|S000146614}} PMID 21904031</ref><ref name='S000082137'>Haas AL, et al. (2005) Thi20, a remarkable enzyme from Saccharomyces cerevisiae with dual thiamin biosynthetic and degradation activities. Bioorg Chem 33(4):338-44 {{SGDpaper|S000082137}} PMID 15967475</ref><ref name='S000056318'>Llorente B, et al. (1999) Genetic redundancy and gene fusion in the genome of the Baker's yeast Saccharomyces cerevisiae: functional characterization of a three-member gene family involved in the thiamine biosynthetic pathway. Mol Microbiol 32(6):1140-52
 
  {{SGDpaper|S000056318}} PMID 10383756</ref>
 
  {{SGDpaper|S000056318}} PMID 10383756</ref>
 
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Latest revision as of 07:45, 23 January 2012

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Systematic name YOL055C
Gene name THI20
Aliases
Feature type ORF, Verified
Coordinates Chr XV:226075..224420
Primary SGDID S000005416


Description of YOL055C: Trifunctional enzyme of thiamine biosynthesis, degradation and salvage; has hydroxymethylpyrimidine (HMP) kinase, HMP-phosphate (HMP-P) kinase and thiaminase activities; member of a gene family with THI21 and THI22; HMP and HMP-P kinase activity redundant with Thi21p[1][2][3]




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References

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  1. French JB, et al. (2011) Structure of trifunctional THI20 from yeast. Acta Crystallogr D Biol Crystallogr 67(Pt 9):784-91 SGD PMID 21904031
  2. Haas AL, et al. (2005) Thi20, a remarkable enzyme from Saccharomyces cerevisiae with dual thiamin biosynthetic and degradation activities. Bioorg Chem 33(4):338-44 SGD PMID 15967475
  3. Llorente B, et al. (1999) Genetic redundancy and gene fusion in the genome of the Baker's yeast Saccharomyces cerevisiae: functional characterization of a three-member gene family involved in the thiamine biosynthetic pathway. Mol Microbiol 32(6):1140-52 SGD PMID 10383756

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