Difference between revisions of "YLR368W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000004360 YLR368W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''MDM30 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''MDM30 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr XII: | + | |nowrap| Chr XII:857540..859336 |
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| − | | | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000004360 |
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| − | '''Description of | + | '''Description of YLR368W:''' F-box component of an SCF ubiquitin protein ligase complex; associates with and is required for Fzo1p ubiquitination and for mitochondria fusion; stimulates nuclear export of specific mRNAs; promotes ubiquitin-mediated degradation of Gal4p in some strains<ref name='S000145143'>Cohen MM, et al. (2011) Sequential requirements for the GTPase domain of the mitofusin Fzo1 and the ubiquitin ligase SCFMdm30 in mitochondrial outer membrane fusion. J Cell Sci 124(Pt 9):1403-10 {{SGDpaper|S000145143}} PMID 21502136</ref><ref name='S000116768'>Durr M, et al. (2006) Nonredundant roles of mitochondria-associated F-box proteins Mfb1 and Mdm30 in maintenance of mitochondrial morphology in yeast. Mol Biol Cell 17(9):3745-55 {{SGDpaper|S000116768}} PMID 16790496</ref><ref name='S000075479'>Fritz S, et al. (2003) Mdm30 is an F-box protein required for maintenance of fusion-competent mitochondria in yeast. Mol Biol Cell 14(6):2303-13 {{SGDpaper|S000075479}} PMID 12808031</ref><ref name='S000081275'>Muratani M, et al. (2005) The F box protein Dsg1/Mdm30 is a transcriptional coactivator that stimulates Gal4 turnover and cotranscriptional mRNA processing. Cell 120(6):887-99 {{SGDpaper|S000081275}} PMID 15797387</ref><ref name='S000060747'>Seol JH, et al. (2001) Skp1 forms multiple protein complexes, including RAVE, a regulator of V-ATPase assembly. Nat Cell Biol 3(4):384-91 {{SGDpaper|S000060747}} PMID 11283612</ref><ref name='S000130017'>Shukla A, et al. (2009) Stimulation of mRNA export by an F-box protein, Mdm30p, in vivo. J Mol Biol 389(2):238-47 |
| − | {{SGDpaper| | + | {{SGDpaper|S000130017}} PMID 19376128</ref> |
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==Community Commentary== | ==Community Commentary== | ||
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| + | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | ||
| + | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | ||
| + | J Biol Chem 278(5):3265-74</ref> | ||
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==References== | ==References== | ||
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Latest revision as of 07:45, 23 January 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YLR368W |
| Gene name | MDM30 |
| Aliases | DSG1 |
| Feature type | ORF, Verified |
| Coordinates | Chr XII:857540..859336 |
| Primary SGDID | S000004360 |
Description of YLR368W: F-box component of an SCF ubiquitin protein ligase complex; associates with and is required for Fzo1p ubiquitination and for mitochondria fusion; stimulates nuclear export of specific mRNAs; promotes ubiquitin-mediated degradation of Gal4p in some strains[1][2][3][4][5][6]
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References
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- ↑ Cohen MM, et al. (2011) Sequential requirements for the GTPase domain of the mitofusin Fzo1 and the ubiquitin ligase SCFMdm30 in mitochondrial outer membrane fusion. J Cell Sci 124(Pt 9):1403-10 SGD PMID 21502136
- ↑ Durr M, et al. (2006) Nonredundant roles of mitochondria-associated F-box proteins Mfb1 and Mdm30 in maintenance of mitochondrial morphology in yeast. Mol Biol Cell 17(9):3745-55 SGD PMID 16790496
- ↑ Fritz S, et al. (2003) Mdm30 is an F-box protein required for maintenance of fusion-competent mitochondria in yeast. Mol Biol Cell 14(6):2303-13 SGD PMID 12808031
- ↑ Muratani M, et al. (2005) The F box protein Dsg1/Mdm30 is a transcriptional coactivator that stimulates Gal4 turnover and cotranscriptional mRNA processing. Cell 120(6):887-99 SGD PMID 15797387
- ↑ Seol JH, et al. (2001) Skp1 forms multiple protein complexes, including RAVE, a regulator of V-ATPase assembly. Nat Cell Biol 3(4):384-91 SGD PMID 11283612
- ↑ Shukla A, et al. (2009) Stimulation of mRNA export by an F-box protein, Mdm30p, in vivo. J Mol Biol 389(2):238-47 SGD PMID 19376128
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