Difference between revisions of "YLR318W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000004310 YLR318W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''EST2 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''EST2 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
|nowrap| Chr XII:766542..769196 | |nowrap| Chr XII:766542..769196 | ||
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| + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000004310 | ||
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| − | '''Description of | + | '''Description of YLR318W:''' Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia<ref name='S000053929'>Lingner J, et al. (1997) Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity. Proc Natl Acad Sci U S A 94(21):11190-5 {{SGDpaper|S000053929}} PMID 9326584</ref><ref name='S000069751'>Livengood AJ, et al. (2002) Essential regions of Saccharomyces cerevisiae telomerase RNA: separate elements for Est1p and Est2p interaction. Mol Cell Biol 22(7):2366-74 {{SGDpaper|S000069751}} PMID 11884619</ref><ref name='S000081260'>Yamaguchi H, et al. (2005) Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia. N Engl J Med 352(14):1413-24 |
| − | {{SGDpaper| | + | {{SGDpaper|S000081260}} PMID 15814878</ref> |
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J Biol Chem 278(5):3265-74</ref> | J Biol Chem 278(5):3265-74</ref> | ||
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Latest revision as of 07:45, 23 January 2012
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| Systematic name | YLR318W |
| Gene name | EST2 |
| Aliases | TERT |
| Feature type | ORF, Verified |
| Coordinates | Chr XII:766542..769196 |
| Primary SGDID | S000004310 |
Description of YLR318W: Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia[1][2][3]
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References
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- ↑ Lingner J, et al. (1997) Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity. Proc Natl Acad Sci U S A 94(21):11190-5 SGD PMID 9326584
- ↑ Livengood AJ, et al. (2002) Essential regions of Saccharomyces cerevisiae telomerase RNA: separate elements for Est1p and Est2p interaction. Mol Cell Biol 22(7):2366-74 SGD PMID 11884619
- ↑ Yamaguchi H, et al. (2005) Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia. N Engl J Med 352(14):1413-24 SGD PMID 15814878
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